Hypoglycemia

Severe Hypoglycemia (Severe Low Blood Glucose)

Severe hypoglycemia should be considered an emergency. Don’t hesitate to call 911, if needed, or if glucagon is not readily available.

What is severe hypoglycemia?

Severe hypoglycemia, which may also be referred to as an insulin reaction or insulin shock, is when your blood glucose (blood sugar) drops dangerously low (but it can occur in those not on insulin). If you have severe hypoglycemia, you may become confused, pass out (lose consciousness), or treatments for a low blood glucose aren’t working.

Who is at risk for severe hypoglycemia?

  • People on blood glucose-reducing medications (insulin, sulfonylureas, or meglitinides)
  • People with a history of severe hypoglycemia

Signs and symptoms of severe hypoglycemia 

  • An altered mental state
  • Fainting or losing consciousness
  • Incredibly weak and unable to help yourself
  • Seizure
  • Coma 

If left untreated for too long, severe hypoglycemia can lead to brain or organ damage or even death. 

Severe Hypoglycemia Treatment

Glucagon, preferably ready-to-use, should be used to treat severe hypoglycemia. It quickly raises blood glucose levels by causing the liver to release the glucose it stores into your bloodstream. 

There are three formulations of glucagon: 

  • Premixed pens/injections (ready-to-use), similar to epinephrine autoinjectors for allergies 
  • Nasal powder (ready-to-use) 
  • Kit that requires mixing a powder and liquid prior to administration 

Ready-to-use glucagon is preferred, widely available, and saves lives. If you are at risk, it's important to have glucagon in your toolkit and for both yourself and any caregivers to know how and when to use it.

If you do not currently have an active glucagon prescription or your glucagon is expired, talk to your doctor as soon as possible about getting one, preferably for a ready-to-use formulation.

By the Numbers

More needs to be done to protect people at risk for severe hypoglycemia. It is estimated that: 

46%

Up to 46% of people with type 1 diabetes and 21% with type 2 diabetes on insulin experience at least one severe hypoglycemic event per year.

95%

Over 95% of patients that had experienced hypoglycemia-related emergencies did not fill their glucagon prescriptions

3X

Severe hypoglycemia is associated with a 3X increased risk of death

This is unacceptable. It’s time to act with urgency to get protected with glucagon, preferably a ready-to-use formulation. Talk to your health care team today!

Back of ambulance driving down street
Back of ambulance driving down street

xerislogo is proud to support the work of the American Diabetes Association® to address severe hypoglycemia.